Given the costs and resources involved, the CIA, Cefic and the Chemical Business Association (CBA) all warned that not all substances would register under the Kingdom of Go Reach. Some chemicals will inevitably disappear from the UK market. This is what happened when Reach was introduced into the EU, says Hollis. „Many substances available in the EU have not been registered under Reach and have therefore been withdrawn from the EU market. Without any form of information exchange, we have no reason to think that the situation will be different in the UK,“ he said. Importer: If you buy something outside the EU/EEA, you probably have some responsibilities under REACH. These may be individual chemicals, resale mixes or finished products such as clothing, furniture or plastic items. Downstream users: Most companies use chemicals, sometimes even without realizing it, which is why you need to check your obligations when handling chemicals in your industrial or professional activity. You may have a few tasks to do as part of REACH.
Substance assessment is part of a program known as the Community Development Action Plan (CORAP). An independent review of the progress made by national officials, published at the end of 2018, revealed that 352 substances had been given priority for the evaluation of substances, 94 of which had been finalized. Almost half of the 94 officials concluded that the existing commercial use of the substance for human health and/or the environment was not safe. Since REACH came into force, 12 substances have been involved in risk management. For 74% of substances (34 out of 46), concerns have been highlighted, but no concrete regulatory action has yet been taken. In addition, national officials concluded that 64% of the substances examined (126 out of 196) did not have the information necessary to demonstrate the safety of chemicals marketed in Europe due to insufficient industrial data. The continued use of many toxic chemicals is sometimes justified because they „do not pose a health problem at very low concentrations.“  However, many of these substances can bioaccumulate in the human body and thus reach dangerous concentrations. They can also react chemically to each other by producing new substances with new risks. REACH is the result of a comprehensive review of EU chemical policy.
It adopted the first reading in the European Parliament on 17 November 2005 and the Council of Ministers reached a political agreement on a common position on 13 December 2005. The European Parliament adopted REACH on 13 December 2006 and the Council of Ministers formally adopted it on 18 December 2006. Balancing expenditure and profits has always been an important issue, given that the estimated cost of complying with the 11-year rules was around EUR 5 billion and the supposed health benefits were being saved by billions of euros in health costs.  However, there have been different studies of estimated costs, which vary considerably in outcome. It came into force on 20 January 2009 and will be fully implemented by 2015. Subsequently, Defra confirmed that the government intends to include formal cooperation in a chemical annex in the potential free trade agreement, supported by an agreement to exchange data and information. REACH also requires companies or individuals who use a chemical, either alone or in a mixture, to pass information, in the course of their industrial or professional activities, to chemical manufacturers and suppliers or to the European Chemicals Agency (ECHA).